Description: EPACHEMINV_AVAIL is a snapshot of the full list of unique DSSTox substances for which DMSO solutions are available through EPA Chemical Contract Services to supply ToxCast and Tox21 cross-partner projects. This inventory includes only those substances deemed soluble in DMSO at 5mM or higher concentrations, and excludes substances marked for volatility or reactivity concerns. EPACHEMINV_AVAIL includes EPA’s previous ToxCast inventory (a subset of (TOXCAST) as well as approximately 1300 chemicals donated by the National Toxicology Program (NTP) as part of the Tox21 chemical library consolidation effort. This recently added NTP set represents the full portion of NTP’s original contribution to the Tox21 library (TOX21SL) that was deemed to be non-overlapping with EPA’s current ToxCast library.
Of the total unique chemicals in EPACHEMINV_AVAIL, approximately 6000 were included in the original TOX21SL library (70% of the total), with the remainder in EPACHEMINV_AVAIL resulting from the continuous expansion of EPA’s ToxCast library. The remaining Tox21 chemicals not included in EPACHEMINV were either discontinued or were drugs originally contributed by the Tox21 NCATS (National Center for Advances in Translational Science) partner; future expansion of EPACHEMINV_AVAIL may include newly procured drugs provided by NCATS. Hence, in addition to supplying new ToxCast projects, EPACHEMINV_AVAIL is intended to serve as the new, consolidated TOX21 library moving forward, as outlined in the recently published Tox21 strategic and operational planning document (available at https://www.ncbi.nlm.nih.gov/pubmed/29529324). The plan articulates areas of focused scientific investment, both in chemical and biological space, to which new Tox21 cross-partner projects will be directed.
For more information on EPA’s ToxCast program, see:
https://www.epa.gov/chemical-research/toxicity-forecasting
For current information on the Tox21 program, see
https://tox21.gov/page/home
Number of Chemicals: 6408