Description: List of chemicals used by EPA researchers to identify reference chemicals for high-throughput phenotypic profiling in U-2 OS cells. List includes 14 reference chemicals from Gustafsdottir et al. 2013 [Gustafsdottir, S. M., et al. "Multiplex cytological profiling assay to measure diverse cellular states." PloS one 8.12 (2013): e80999.], two negative controls and two cytotoxic chemicals. For more information, see: Nyffeler et al., Bioactivity screening of environmental chemicals using high-throughput phenotypic profiling (submitted for publication). See also HTPP2019_SCREEN.
Number of Chemicals: 18